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Bader, Kenneth
One or more keywords matched the following properties of Bader, Kenneth
PropertyValue
keywords Therapeutic ultrasound
keywords Diagnostic ultrasound
overview The focus of the Biomedical Acoustics Development and Engineering Research Laboratory (BADER Lab) is the translation of therapeutic ultrasound for non- or minimally invasive treatment of cardiovascular and cancerous disease. Specifically, we utilize acoustic cavitation for combinatorial ablation and enhanced drug delivery treatment strategies of pathologies resistant to standard interventional techniques. To assess bubble activity and the resultant changes in tissue structure, we are developing multi-modal imaging approaches via diagnostic ultrasound and magnetic resonance imaging. Analytic and numerical bubble dynamics models are also utilized to gain insight into the mechanism of action of our therapeutic approaches. Current research topics include: • Chronic thrombus ablation with histotripsy and thrombolytic drugs • Passive cavitation and MR imaging to assess histotripsy-induced liquefaction • In vitro assessment of histotripsy-enhanced drug delivery • Histotripsy-induced sonochemical reactions for the treatment of cancer • Numeric and analytic models of bubble dynamics • Magnetic Resonance-guided transurethral prostate ablation For more information, visit our laboratory website: baderlab.uchicago.edu
One or more keywords matched the following items that are connected to Bader, Kenneth
Item TypeName
Concept Combined Modality Therapy
Concept High-Intensity Focused Ultrasound Ablation
Concept Ultrasonic Therapy
Concept Thrombolytic Therapy
Academic Article Thrombolytic efficacy and enzymatic activity of rt-PA-loaded echogenic liposomes.
Academic Article Relationship between cavitation and loss of echogenicity from ultrasound contrast agents.
Academic Article Shaken and stirred: mechanisms of ultrasound-enhanced thrombolysis.
Academic Article Efficacy of histotripsy combined with rt-PA in vitro.
Academic Article Cavitation thresholds of contrast agents in an in vitro human clot model exposed to 120-kHz ultrasound.
Academic Article Gauging the likelihood of stable cavitation from ultrasound contrast agents.
Academic Article Effect of Frequency-Dependent Attenuation on Predicted Histotripsy Waveforms in Tissue-Mimicking Phantoms.
Academic Article Experimental validation of a finite-difference model for the prediction of transcranial ultrasound fields based on CT images.
Academic Article Sonothrombolysis.
Academic Article Predicting the growth of nanoscale nuclei by histotripsy pulses.
Academic Article Broadband attenuation measurements of phospholipid-shelled ultrasound contrast agents.
Academic Article Quantitative Frequency-Domain Passive Cavitation Imaging.
Academic Article In vitro thrombolytic efficacy of echogenic liposomes loaded with tissue plasminogen activator and octafluoropropane gas.
Academic Article MRI-guided transurethral insonation of silica-shell phase-shift emulsions in the prostate with an advanced navigation platform.
Academic Article Post Hoc Analysis of Passive Cavitation Imaging for Classification of Histotripsy-Induced Liquefaction in Vitro.
Academic Article The influence of medium elasticity on the prediction of histotripsy-induced bubble expansion and erythrocyte viability.
Academic Article For Whom the Bubble Grows: Physical Principles of Bubble Nucleation and Dynamics in Histotripsy Ultrasound Therapy.
Academic Article Assessment of histotripsy-induced liquefaction with diagnostic ultrasound and magnetic resonance imaging in vitro and ex vivo.
Academic Article Corrigendum to: "Shaken and Stirred: Mechanisms of Ultrasound-Enhanced Thrombolysis" in Ultrasound Med Biol 2015; 41(1): 187-196.
Academic Article In vitro assessment of stiffness-dependent histotripsy bubble cloud activity in gel phantoms and blood clots.
Academic Article In Vitro Thrombolytic Efficacy of Single- and Five-Cycle Histotripsy Pulses and rt-PA.
Academic Article Assessment of Collaborative Robot (Cobot)-Assisted Histotripsy for Venous Clot Ablation.
Academic Article Clot Degradation Under the Action of Histotripsy Bubble Activity and a Lytic Drug.
Academic Article An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug.
Academic Article Design and Characterization of an Ultrasound Transducer for Combined Histotripsy-Thrombolytic Therapy.
Academic Article Ultrasound for Aesthetic Applications: A Review of Biophysical Mechanisms and Safety.
Academic Article (More than) doubling down: Effective fibrinolysis at a reduced rt-PA dose for catheter-directed thrombolysis combined with histotripsy.
Academic Article Effect of Thrombin and Incubation Time on Porcine Whole Blood Clot Elasticity and Recombinant Tissue Plasminogen Activator Susceptibility.
Academic Article Corrigendum: Assessment of histotripsy-induced liquefaction with diagnostic ultrasound and magnetic resonance imagingin vitroandex vivo(2019Phys. Med. Biol.64095023).
Academic Article Assessment of bubble activity generated by histotripsy combined with echogenic liposomes.
Academic Article Histotripsy induces apoptosis and reduces hypoxia in a neuroblastoma xenograft model.
Academic Article Contrast-Enhanced Imaging of Histotripsy Bubble Clouds Using Chirp-Coded Excitation and Volterra Filtering.
Academic Article Development of Convolutional Neural Network to Segment Ultrasound Images of Histotripsy Ablation.
Search Criteria
  • Therapeutic
  • ultrasound